When it comes to transporting specific genes to human body tissues for treatment, the probability of successful treatment becomes unpredictable. Make predictions. Recently, researchers from the University of Wisconsin-Madison have developed a new screening technology that can simplify non-viral transfection, which provides a method for researchers and doctors. To find an optimal model of biological materials to transport genes into cells. Related research results are published in the international journal Scientific Reports.
This new method will allow researchers to control the cell to a greater degree, and can control the cell's response to the gene transport mechanism. This broad-spectrum technique is a very subtle method that can effectively control cell behavior. Researcher Murphy said, we use adult cell reprogramming technology to develop this method, and this method can well control the differentiation of stem cells.
In current successful methods, researchers use specialized viruses to transport genetic material into cells. Although this method is effective, it may also turn on other unnecessary genes in the body or stimulate the body's immune response, making biomedical applications less attractive, such as programs that control stem cell behavior.
Researchers have developed a virus-independent method. The researchers use a special calcium phosphate coating as a medium to efficiently transport genetic material into cells. By pairing the coating with special application software to transport genes, the researchers increased the success rate of gene expression in stem cells by 70-fold.
Researchers say that from the perspective of applications, technological advances and innovations are indeed very useful, and can make gene delivery into a relatively complete part of medical device design and tissue engineering applications.
This research result is very critical for the future of regenerative medicine. In the future, researchers can provide patients with tissue engineering structures of any size and shape, which will provide researchers with a convenient path to build complex tissue structures for conducting. Next-generation drug screening technology research and development and patient-specific therapy. Related research results are funded by the AO Foundation and NIH.
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