Xinhua News Agency, Hefei, October 15: The reporter learned from the Hefei Institute of Substances, Chinese Academy of Sciences that recently, Chinese and American scientists have jointly developed a new type of inhibitor, DDR1-IN-1, and applied high-throughput screening technology and combined pharmaceutical methods The combination of the inhibitor and another kinase inhibitor GSK2126458 can significantly enhance its ability to kill colorectal cancer cells. According to reports, the research center Liu Qingsong led by the strong magnetic field science center of the Chinese Academy of Sciences led the research team to cooperate with two research groups of the Harvard Medical School in the United States. Designed and developed small molecule compounds DDR1-IN-1 and DDR1-IN-2 targeting DDR1 kinase. After conducting a series of in vitro biochemical tests on these two compounds, the study found that DDR1-IN-1 and DDR1-IN-2 have an inhibitory effect on the autophosphorylation of DDR1 kinase, and DDR1-IN-1 has an effect on DDR1 kinase Very selective. This shows that DDR1 may work with other signaling pathways in the development of cancer. The results of this study were published online in the Journal of the American Chemical Society · Chemical Biology. Experts say that at present, people's understanding of the specific role of DDR1 in the pathological process of cancer is still very limited. The discovery of the selective inhibitor DDR1-IN-1 is to further reveal the physiological and pathological functions of DDR1 kinase in the human body, and To verify whether DDR1 can be used as a target for anti-cancer drug development has laid the foundation.
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