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China Science and Technology News is well known that stem cells can treat myocardial infarction. However, the results of hundreds of clinical trials worldwide have shown that the low survival rate of transplanted cells is not ideal. Zeng Chunyu, director of the Department of Cardiology of the Daping Hospital of the Third Military Medical University, led the research team through three years of research to develop "drought-tolerant" stem cells resistant to ischemia and hypoxia, so that the survival rate of the transplanted cells was increased by one Times, bringing dawn to stem cell therapy for myocardial infarction. A few days ago, the paper written by the team was published in the latest international journal of basic cardiovascular research, the latest issue of the American Journal of Circulation Research.
The results of previous clinical trials prove that the main reason for the unsatisfactory effect of transplanted stem cells is the low survival rate of stem cells in the transplanted microenvironment of ischemia and hypoxia. With current transplantation techniques, the survival rate of transplanted stem cells in a heart with myocardial infarction is only about 8%. Zeng Chunyu's research team fixed the scientific thinking on developing a kind of ischemic and hypoxic-resistant stem cells similar to "drought-tolerant rice".
Studies have shown that high expression of a key gene hypoxia-inducible factor in stem cells can promote the survival of stem cells in a hypoxic environment and has a "drought tolerance" effect, but hypoxia-inducible factors are not stable, and reoxygenation can easily cause it degradation. The research team based on the principle of proline hydroxylase 2 as an important oxygen receptor, not only has the regulation of the stable expression of hypoxia-inducible factors, but also regulates the function of another transcription factor nuclear factor, using lentivirus transfection method Silencing the proline hydroxylase 2 gene in stem cells developed "drought-tolerant" stem cells.
The research team ligated the left anterior descending branch of the mouse heart to form an acute myocardial infarction model, and then transplanted these "drought-tolerant" stem cells into the heart of the myocardial infarction mouse. It was found that the survival rate of stem cells in the infarcted heart was 8% Increased around 16.7%. "Drought-tolerant" stem cells not only increase the number of surviving stem cells, but also enhance the therapeutic effect of individual stem cells, but also increase the secretion of growth factors by 3-4 times, and the effect of protecting ischemic myocardium is significantly enhanced. Research data show that the "drought-tolerant" stem cells significantly inhibited myocardial infarction and approached the normal ejection fraction, proving its extraordinary efficacy.
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