Recently, Plos One published the latest research results of the collaboration between Ji Hongbin's research group, Liu Xinyuan's research group and Dr. Kwok-Kin Wong of Harvard University in Shanghai In Vivo Using a Regulatable K-rasG12D Mouse Allele, reveals the important role of K-ras mutants in the occurrence, development and survival of lung cancer.
Lung cancer is one of the major diseases that seriously endanger the life and health of our people. Revealing the role of key pathogenic genes in the development and survival of lung cancer will provide potential drug targets and clinical targets for the "individualized" molecular targeted therapy of lung cancer. New strategy; and the mouse model of air-conditioning gene expression can better promote the molecular mechanism of lung cancer. At present, the most widely used animal model of lung cancer in the world is the LSL-K-rasG12D mouse model. K-ras can be achieved by intranasal instillation of adenovirus carrying Cre-expressing genes or hybridization with Cre transgenic mice specific for lung epithelial cells The activation of the mutant leads to the occurrence of lung cancer; the only drawback of this model is that once the K-ras mutant is activated, its expression and activity cannot be regulated.
Recently, Ji Hongbin's research group and Liu Xinyuan's research group have built a mouse model LSL-ER-K-rasG12D based on the LSL-K-rasG12D mouse model to control the expression of K-ras mutants. The expression of ER-KrasG12D can be induced by CRE, while the activation of ER-K-rasG12D protein can be regulated by Tamoxifen. Studies in mouse embryonic fibroblasts have shown that Tamoxifen treatment can induce the activation of ER-K-rasG12D, promoting abnormal cell proliferation, malignant transformation, and invasion and infiltration; and after removal of Tamoxifen, mouse embryonic fibroblasts proliferate The ability of transformation and invasion can be basically restored to normal levels; in vivo animal studies have found that intraperitoneal injection of mice Tamoxifen can continuously activate K-rasG12D and promote the early development of lung tumors in mice, and most lung tumors after Tamoxifen was withdrawn Apoptosis will occur.
This work has greatly improved people's understanding of the role of K-ras mutants in the occurrence, development and survival of lung cancer, and provides an ideal research system for the future in-depth study of the molecular mechanism of lung cancer pathogenesis. The establishment and development of the model is of great significance.
The research project was supported by funding from the Ministry of Science and Technology, the National Natural Science Foundation of China and the Shanghai Municipal Science and Technology Commission.
Non Woven Fabric is a kind of nonwoven fabric with extensive uses. Nonwoven fabric is also a new generation of environmental protection material. It has the characteristics of moisture-proof, breathable, flexible, light, non-combustion-supporting, easy to decompose, non-toxic and non-irritating, rich color, low price and recyclable. but how to get this kind of non woven fabrics which have good quality and competitive price ? Sunway is a professional manufacturer of packaging material, we are focused on the manufacture and sales of non woven fabrics is more than 20 years, it's here you can find all kinds of non woven fabrics which you want. The size , thickness and colors are based on your requirements, you can choose the color from 1 to 12, we can provide the best quality and price for you , welcome to contact us.
Non Woven Fabric
Non Woven Fabric,Spunbond Non Woven Fabric,PP Non Woven Fabric,Polyester Non Woven Fabric
Shenzhen Sunway Packaging Material Co., Ltd , https://www.sunwaypack.com